Description
Osteopontin (OPN) is also known as Secreted phosphoprotein 1 (SPP1), Bone sialoprotein 1, Nephropontin, Urinary stone protein, Uropontin, BNSP, which belongs to the osteopontin family.
OPN / SPP1 is a highly negatively charged, extracellular matrix protein that lacks an extensive secondary structure.
Full length OPN (OPN-FL) can be modified by thrombin cleavage, which exposes a cryptic sequence, SVVYGLR on the cleaved form of the protein known as OPN-R.
Osteopontin / SPP-1 is biosynthesized by a variety of tissue types.
OPN is the ligand for integrin alpha-V/beta-3.
OPN / SPP1 binds tightly to hydroxyapatite and appears to form an integral part of the mineralized matrix.
OPN / SPP1 probably important to cell-matrix interaction.
OPN / SPP1 acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity